Four of the players who are doubts for their clubs this weekend (Getty images)
The international break always poses different questions to managers, from injuries to form and fatigue.
Premier League managers get a few days away from the intense training sessions but watch every game with bated breath, hoping their players return with a clean bill of health.
Some even reach out to national team coaches, asking for playing time to be managed.
So as with all international breaks, LondonWorld.com brings you a list of all players who have picked up knocks ahead of match day eight in the Premier League.
Thomas Tuchel is anxiously waiting for the reaction of striker Romelu Lukaku who was rested in the National League third place play-off against Italy on Sunday due to muscle fatigue.
In-form defender Antonio Rudiger also picked up a back problem that forced him to miss Germany’s World Cup qualifier against North Macedonia.
German manager Thomas Tuchel is already without veteran Thiago Silva who will not return to London in time to feature against Brentford on Saturday.
In some positive news for Thomas Tuchel, both N’Golo Kante and Reece James are all back in training and should be available for sellection.
Arsenal manager Mikel Arteta will be happy to know that Thomas Partey came out unscathed after playing 90 minutes in both Ghana’s World Cup qualifiers against Zimbabwe.
He was seen with a huge ice on his leg after the game in Harare but Ghana’s team doctors say it’s nothing serious.
Granit Xhaka remains a long term absentee.
Brentford have got no injury concerns this international break and will be hoping that they continue their fine form when Chelsea visit this Saturday.
Shandon Baptiste (shoulder) and Joshua Dasilva (groin) have long term juries and the club has not provided a date for their return.
Harry Kane was replaced by Tammy Abraham as England battled to a 1-1 against Hungary on Tuesday night but the change was necessitated by form rather than injury.
There is also growing belief within Hotspur Way that winger Steven Bergwijn could be fit for the trip to Newcastle over the weekend.
David Moyes will be hoping that his team responds to the last gasp defeat to Brentford when they face Everton this weekend.
West Ham have no immediate health issues from the international break even though Ryan Fredericks (pelvic injury) and (groin) are still nursing injuries.
Patrick Vieira will be boosted by the return of Eberechi Eze to out door training but the London derby against Arsenal on Monday night will come too early for the promising midfielder.
Claudio Ranieri has a lot of injury concerns ahead of his Watford debut this weekend. Peter Etebo picked up a thigh injury and there is currently no date for his return.
Both Christian Kabasele Joshua King are also doubts for this weekend’s game due to thigh complications.