Crystal Palace star Michael Olise is reportedly facing up to two months on the sidelines having re-aggravated a hamstring injury against Brighton last weekend.
Roy Hodgson's decision to bring the player, who had been fighting a muscle strain already, on from the bench with the side 3-0 down has been criticised by Eagles supporters who know just how important the former Reading man is to their play. Crystal Palace are also without the influential Eberechi Eze at the moment as injuries have a serious knock-on effect on the side's form.
The South London club aren't the only ones in the Premier League struggling with player fitness - there's a well-publicised injury crisis at Newcastle United at the moment and Chelsea are also without key stars.
LondonWorld looks at how many players each top flight side are missing as it stands with injury information taken from the Premier League website. Players who are suspended or whose absence is related to international duty have an asterisk.
1. Manchester City - 0
Doubts - 0 Outs - 0 Photo: Getty Images
2. Wolves - 2
Doubts - Boubacar Traore*, Hwang Hee-chan*. Outs - None. Photo: Getty Images
3. West Ham - 2
Doubts - Lucas Paqueta, Michail Antonio. Outs - None. Photo: Getty Images
4. Luton Town - 3
Doubts - None. Outs - Tom Lockyer, Mads Andersen, Marvelous Nakamba. Photo: Getty Images