Ansgar Knauff gave Frankfurt the lead after 49 seconds in a 2-1 win in London - and turned provider for the only goal in Germany, setting up the exciting Rafael Borre for his goal to complete a 3-1 scoreline.
The German side were the best team in both legs and even though West Ham had a mountain to climb following the sending off of left-back Cresswell, experienced attacker Andriy Yarmolenko says no one in the dressing room is blaming their teammate.
Ukrainian Yarmolenko said: “No one in the dressing room is blaming him, he has helped us a lot in games and this is football, we win together and we lose together so it’s unfair to just pin that on him.”
The Hammers also had manager David Moyes sent off with a straight red after booting the ball angrily towards a ball boy who was retrieving it.
Tempers boiled over but the experienced manager quickly apologised after he was questioned by reporters after the game.
West Ham manager David Moyes said: “ “I have to apologise for kicking the ball.
“The ball boy left it short nicely on the volley for me. I apologise for it. It didn’t hit him, I think I bent it past him.”
The Hammers will now hope they pick themselves up after losing their last four games in all competitions to finish with a flourish in the Premier League.
They will take on Norwich this weekend before games against Manchester City and Brighton Hove and ALbion come along.