The Hammers are working on a move to lure the attacker to the Premier League to bolster their options up top.
David Moyes’ side are in Europe again next season and could see the Italy international as someone to offer them something different up top.
90min claim the London club have agreed a deal in principle with the two clubs yet to agree an exact transfer fee at this stage.
Talks between the two parties are expected to continue ‘talks’ over the coming days.
Scamacca has been with Sassuolo since 2017 but has spent the majority of his time with the Serie A club out on loan.
He joined them from PSV and has since been shipped out on loan to Cremonese, PEC Zwolle, Ascoli and Genoa to gain experience.
The forward returned to his parent club last summer with a spring in his step and ended up firing 16 goals in all competitions.
That goal return has seen him emerge on the radar of West Ham and they are now trying to bring him to England.
Check out the latest Premier League transfer speculation below...
5. Traore in demand
Everton, Leeds United, Tottenham and West Ham are all interested in Adama Traore, and Wolves would accept £10m for him this summer. (Express & Star) | Getty Images
6. Leeds prepared to pay big for De Ketelaere
Leeds United are prepared to pay a club record fee of around £31.6m to sign Charles De Ketelaere from Club Brugge. (Mirror) | BELGA MAG/AFP via Getty Images
7. Albion hold Bassey talks
Brighton and Dutch champions Ajax have held initial talks with Rangers over the potential signing of defender Calvin Bassey. The Gers want at least £20m for the player. (BBC) | Getty Images
8. Leeds want Pepe
Leeds United want to sign Arsenal winger Nicolas Pepe, but could face competition from Lyon and Marseille. (Diario de Sevilla) | Arsenal FC via Getty Images