The England striker was tied with the French legend on 43 goals coming into the game - but his well struck penalty past Ramsdale took him clear off the Arsenal great even though Spurs would go on to lose the 3-1, their first defeat of the campaign in the Premier League.
Spurs got back in after a costly error from defender Gabriel Magalhaes gave Kane a perfect opportunity to slot home the equaliser from a penalty spot.
Arsenal then took it away from their arch-rivals after a howler from the often reliable Hugo Lloris allowed Gabriel Jesus to net his fifth goal of the season.
Granit Xhaka who has completed one of the most remarkable turnarounds in Premier League history then sealed the win with a low strike to ensure Arsenal forced Spurs into submission and into defeat.
Tottenham need to get back to winning ways straight away
Spurs have now lost two of their last three games in all competition and will be desperate to return to winning ways against Eintracht Frankfurt in the Champions League Tuesday night.
The Lillywhites lost to Sporting Lisbon in the second game of the group stages and know that they can’t afford to slip against the Germans if they are to secure a top spot in the group.
In the Premier League, Spurs are still third, three points ahead of fourth placed Brighton and Hove Albion.
They are also just five four points behind leaders Arsenal and with just eight games played, they will feel they have enough in them to catch up.