The midfielder was in line to start against the Selecao but felt a sharp pain in his knee during warm-up resulting in his replacement.
He watched on from the stands as Ghana lost 3-0 to Tite’s team as part of preparations for the World Cup to be staged in Qatar later this year.
He has already missed three Premier League games for the Gunners this season and only returned to the team for the 3-0 win over Brentford just before the international break.
With barely days to the North London derby- the Gunners will hope that their star midfielder is able to shake off any pain and take part in the biggest game of the campaign so far.
Another cause for concern for manager Mikel Arteta has been Kieran Tierney who was forced off during Scotland’s Nations League game against Ireland.
Last season the Scottish left back raptured his knee and missed the last part of the campaign and his return to full fitness has been met with the Gunners signing Oleksandr Zinchenko from Manchester City as direct competition.
He has shown strength and willingness to compete for his spot in the starting 11 which will make the injury on international duty worrying for his manager.
Arsenal have made a brilliant start to the season with six wins from their first seven games , the only defeat coming against Manchester United at Old Trafford.
They will take on third-placed Tottenham in the first game after the current international break.