Barts Health NHS Trust was caring for 75 coronavirus patients in hospital as of Wednesday, figures show.
NHS England data shows the number of people being treated in hospital for Covid-19 by 8am on November 23 was down from 101 on the same day the previous week.
The number of beds at Barts Health NHS Trust occupied by people who tested positive for Covid-19 decreased by 42% in the last four weeks – 28 days ago, there were 129.
Across England there were 4,600 people in hospital with Covid as of November 23, with 117 of them in mechanical ventilation beds.
The number of Covid-19 patients hospitalised nationally has decreased by 50% in the last four weeks, while the number on mechanical ventilators has decreased by 47%.
The figures also show that 31 new Covid patients were admitted to hospital in Barts Health NHS Trust in the week to November 21. This was down from 34 in the previous seven days.