Tottenham finished last season on form and took Champions League football from the jaws of Arsenal, their north London rivals.
So Antonio Conte will be looking at starting the season as they ended the last one, with a win.
Spurs fans have high hopes going into the new campaign, with the exciting signings of Richarlison, Ivan Perisic, Yves Bissouma and others.
Southampton finished 15th and lost their final pre-season game, and have often looked susceptible to Golden Boot winner Son Heung-Min’s pace in attack.
Tottenham have not played a lot of pre-season games, just the four, and they lost the final one against former manager Jose Mourinho’s side AS Roma.
They will be quite desperate to return to winning ways this weekend at home, just to give the team that feeling of being on the winning side and get back on track.
Spurs have brought in six new signings to add quality to the squad and give the manager extra options, given they have Champions League football this season.
For Southampton, they lost their final four games of the season and they will be desperate to avoid a horrendous start that could leave them in trouble from the very beginning.
They certainly do have the tendency to cause an upset, but given that it’s the first match of the season, it’s hard to tell what kind of threat they will pose.
Antonio Conte has some big calls to make - mainly whether first-choice wing backs Matt Doherty and Ivan Perisic are fit to start.
There is also competition at centre back with the arrival of Clement Lenglet, while Richarlison is suspended.
So with all eyes on the Tottenham Hotspur stadium, this is how we predict the Italian manager will line up.
1. Hugo Lloris
The captain and leader signed a new two-year deal, but you’d think this season is one of the biggest in his career.
2. Cristian Romero
An outstanding professional who has showed that he is one of the best in the team. Interesting season ahead for him.
3. Eric Dier
The best defender for Spurs last season and the hope is that he will build on that this season and look to try and get back in the England team.
4. Ben Davies
The unsung hero of this Spurs team, and will start the season as he did last time.