The excellent Cristiano Ronaldo was in inspired form and volleyed home the first goal before setting up Edinson Cavani for Manchester United’s second goal of the game.
Substitute Marcus Rashford wrapped up proceedings for the visitors with a well taken finish to ease pressure on manager Ole Gunnar Solskjær.
Tottenham fans turned on their own manager Nuno Espirito Santo after he hooked the hard-working Lucas Moura for Steven Bergwijn early in the second half.
A section of the fans called for his head after the final whistle and with Spurs dropping down to eighth on the league table, the next few games will be pivotal for the Nuno’s men.
Below we compare how Tottenham have performed in the first 10 league games under Nuno against Jose Mourinho’s last season.
Tottenham results after 10 league games last season
Tottenham 0:1 Everton
Southampton 2: 5 Tottenham
Tottenham 1-1 Newcastle
Manchester United 1-6 Tottenham
Tottenham 3-3 West Ham United
Burnley 0- 1 Tottenham
Tottenham 2- 1 Brighton Hove and Albion
West Brom 0- 1 Tottenham
Tottenham 2-0 Manchester City
Chelsea 0-0 Tottenham
Points : 21
Tottenham results after 10 games this season
Tottenham 1-0 Manchester City
Wolves 0- 1 Tottenham
Tottenham 1- 0 Watford
Crystal Palace 3-0 Tottenham
Tottenham 0-3 Chelsea
Arsenal 3-1 Tottenham
Tottenham 2- 1 Aston Villa
Newcastle 2- 3 Tottenham
West Ham 1- 0 Tottenham
Drop in form from both Son and Kane
Under Mourinho, Kane and Son formed one of the most deadly partnerships in Premier League history.
The duo broke a 25-year-old long standing record for goal combination in a single season in the Premier League.
They combined 14 times for goals, overtaking Alan Shearer and Chris Sutton, who scored 13 goals at Blackburn Rovers during the 1994-95 season.
They have only combined for one goal in the league this season and that was against Newcastle.
Kane also went on to win his third Premier League Golden Boot after netting 24 times,even if Jose Mourinho was gone by then, most of the hard work was done in the first half of the season under the Portuguese manager.
They will have to start finding each other more often if they are to get close to finishing in a Champions League spot.
Drop in expectation from the fans
Tottenham seems to have lowered their expectation with the appointment of Nuno as the fan base have moved on from expecting to win a trophy to wanting just a finish in top four.
Three narrow wins in the first three games of the season raised hopes of a special season but what has ensued since has been just bang average.
If you were to give Tottenham fans a top four finish at this stage of the season most of them would easily take it and write off what is left of the season.