Ange Postecoglou's side currently sit fifth in the Premier League following their 4-0 win over Aston Villa last Sunday. James Maddison, Brennan Johnson, Son Heung-Min and Timo Werner all added their names to the scorecard with Villa and Scotland star John McGinn being sent off in the 65th minute of the match.
With one game in hand, they are now two points behind Unai Emery's side as the race for the final Champions League spot continues to heat up and they will look to continue their run of three wins in four fixtures as they take on fellow Londoners Fulham this weekend.
The Craven Cottage side currently sit 12th having suffered a 2-1 defeat to Wolves last Saturday. However strong results against Brighton and Manchester United will give Marco Silva's side hope that they can successfully take on the Lilywhites this Saturday.
Ahead of the 5.30pm clash, here is the latest injury news from both Silva and Postecoglou's squads...
1. Raul Jimenez - Fulham
Doubt - Jimenez could well return after suffering a thigh injury. He has been involved in full training for the past two weeks.
2. Ryan Sessegnon - Tottenham
OUT - Sessegnon has had surgery on his right hamstring and will be out for the rest of the season.
3. Fraser Forster - Tottenham
OUT - the Goalkeeper picked up a knock in training and will be out for at least two months.
4. Manor Solomon - Tottenham
OUT - After a further procedure on his knee, it is likely Solomon will return at the end of March.