The Blues will also likely welcome Ross Barkley who is likely to make his debut for the visitors tonight as well as hope that Mauricio Pochettino’s side doesn't pick up any injuries, they managed two in east London.
Carney Chukwuemeka has undergone surgery since they last played and Mykhailo Mudryk who came in for him has picked up an injury in training so not the best of times at the Bridge.
The good news is that Chelsea have won all their last three meeting against Luton so on paper this should be a routine win and a chance to get some much-needed confidence in players.
Raheem Sterling will look back to his brilliant best in the game against West Ham so he will look to continue his fine form while Caicedo will hope to have a better home debut than he did at the London Stadium over the weekend.
This is the first league meeting between the teams since they met in the top flight at Kenilworth Road in December 1991, when the Hatters won 2-0.
With just a week to shut the transfer window Chelsea striker Nicolas Jackson will hope he gets a goal after impressing in his two league games.
So with everything in mind- here is how Mauricio Pochettino has set up his team.