The two Premier League clubs came head-to-head as part of their pre-season tour of the US and faced off at the M&T Bank Stadium in Baltimore.
Two goals in three minutes by Gabriel Jesus and Bukayo Saka confirmed the win for the Gunners, with the former scoring his third goal in two matches for his new team.
Arsenal will face Orlando City on Thursday, before facing Chelsea in the Florida Cup on Sunday, followed by the Emirates Cup clash with Sevilla the following weekend.
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Two goals in three minutes by Gabriel Jesus and Bukayo Saka confirmed the win for the Gunners, with the former scoring his third goal in two matches for his new team.