The 23-year-old was handed her first international call-up by England boss Sarina Wiegman last month but won’t be fulfilling her duties.
This week, the Lionesses are at the Lensbury resort in west London making preparations for friendlies against the United States and the Czech Republic.
Parker, meanwhile, remains at West Ham where she is undergoing rehabilitation after picking up a knock during the Hammers’ Continental Cup game against London City Lionesses.
It’s a huge blow for the Cambridge-born centre-back, who last week joked that she had bought Wembley tickets for the match she could possibly feature in.
On Wednesday, Parker took to Twitter to share her disappointment.
“Football can be cruel, and this feeling will take some time to process,” wrote Parker, who has played every Women’s Super League minute for Paul Konchesky’s side this season.
“Heartbroken doesn’t cover it.
“Another obstacle to overcome, but I will be back stronger once again.”
West Ham boss Konchesky sent the youngster message of support: “You got this Luce! Stay strong, keep fighting and ur [sic] be back stronger.”
Fans have also been reacting to the news of Parker’s withdrawal:
@Philippaako: So gutted for Lucy Parker. So many injuries surrounding this friendly at the moment!
@Naomiwfc: I feel so sorry for Leah Williamson, Lucy Parker and Russo.
@Jungleperrie: Such a shame for Lucy Parker on her first senior call-up.
@Halosmoment: I’m heartbroken for Lucy Parker.
@JaneHay0712: Stay strong Lucy, we are all rooting for you and are gutted for you. You'll be back!
@Felloffalorry: Wishing you the best of recoveries, I was delighted to see your call-up so keep up the hard work and keep pinging the Lionesses radar.
@Ho_pe789: Gutted for you. Heal soon.
@Lesleyhayes0611: Gutted for you. You’ll be back stronger than ever.
Euro 2022 stars Leah Williamson and Alessia Russo have also withdrawn from the training camp, forcing Wiegman to call up Manchester United’s Nikita Parris and Arsenal’s Lotte Wubben-Moy last minute.