So Antonio Conte will be looking at starting the season as they ended the last one, with a win.
Southampton finished 15th and lost their final pre-season game, and have often looked susceptible to Golden Boot winner Son Heung-Min’s pace in attack.
Tottenham have not played a lot of pre-season games, just the four, and they lost the final one against former manager Jose Mourinho’s side AS Roma.
They will be quite desperate to return to winning ways this weekend at home, just to give the team that feeling of being on the winning side and get back on track.
Spurs have brought in six new signings to add quality to the squad and give the manager extra options, given they have Champions League football this season.
For Southampton, they lost their final four games of the season and they will be desperate to avoid a horrendous start that could leave them in trouble from the very beginning.
They certainly do have the tendency to cause an upset, but given that it’s the first match of the season, it’s hard to tell what kind of threat they will pose.
Antonio Conte has some big calls to make - mainly whether first-choice wing backs Matt Doherty and Ivan Perisic are fit to start.
There is also competition at centre back with the arrival of Clement Lenglet, while Richarlison is suspended.
So with all eyes on the Tottenham Hotspur stadium, this is how we predict the Italian manager will line up.