Mikel Arteta’s side were unfortunate to not get all three points from their 1-1 draw against Brentford on Saturday.
An error from the VAR at Stockley Park saw Ivan Toney’s goal stand when it should have been ruled out due to Christian Norgaard being in an offside position.
Arsenal were understandably furious at the time but those feelings have quickly wavered into focus and concentration ahead of arguably the biggest game of the season so far.
Former Manchester City forward Gabriel Jesus is still a few weeks from returning to full fitness, while Emile Smith Row is not yet in contention to be involved.
City boss Pep Guardiola has suggested that Erling Haaland may be doubtful for Wednesday’s game, although it remains to be seen whether or not he’ll be selected for the game at Emirates Stadium.
Here is a look at how Arsenal could choose to line up in their pivotal league encounter:
1. GK - Aaron Ramsdale
First choice and will continue between the sticks.
2. RB - Takehiro Tomiyasu
Arsenal have lacked a natural right back in recent games and Tomiyasu warrants an opportunity to start. Photo: David Price
3. CB - Gabriel
As expected, the Brazil international will start at centre back.
4. CB - William Saliba
Hasn’t been at his best level in recent games but will almost certainly continue in defence. Photo: Stuart MacFarlane